AI Agent+DeSci: A Look at the Hottest Memes under Dual-Drive

Original Title: "A Comprehensive Look at Popular Memes Under the Dual Drive of AI Agent and DeSci"

Original Author: Ac-Core, YBB Capital Research

Foreword

Over the past six months, a wave of emerging forces related to AI Agent and DeSci has swept the market. From the perspective of Meme narratives, AI Agent focuses on its significant potential in autonomous decision-making, data analysis, and task execution, excelling in problem-solving through algorithms; while DeSci is committed to leveraging blockchain technology to break the traditional barriers of research, achieve data sharing and transparency, promote decentralized knowledge sharing, and research funding. This article will summarize and categorize the current prominent and promising AI Agent and DeSci-related meme tokens.

1. AI Agent's Intelligent AI Carriage

1.1 What is an AI Agent

An AI Agent is an intelligent system with autonomy and goal orientation, capable of perceiving the environment, planning actions, executing tasks, and learning from experience to improve, achieving specific goals without human intervention, such as automatically monitoring data, analyzing anomalies, and making corresponding decisions. Its key features are autonomy and goal orientation.

According to Messari data as of December 31, 2024, the current trend of AI is similar to the nascent stage of the DeFi boom in 2020-2021. The next day, A16z also proposed some ideas for AI Agents in 2025: AI agents need independent wallets; decentralized autonomous chatbots; as artificial intelligence usage becomes more widespread, unique proofs of different AI personalities are increasingly needed.

1.2 Popular Token Inventory

(Note: The following list is based on Cookie DAO's dynamic Mindshare consumer mindshare ranking order)

· AIXBT (@aixbt_agent)

Market Cap: $5.5 Billion, Mindshare: 20.7%

"AIXBT tracks hot discussions on crypto Twitter and uses its proprietary engine to identify compelling narratives and games... AIXBT token holders can access its analytics platform."

· Virtuals ( @virtuals_io)

Market Cap: $40 Billion, Mindshare: 20.7%

Virtuals has designed an Initial Agent Offering (IAO) model where users can generate new AI agents by locking up $VIRTUAL, and the created tokens will automatically pair with the locked $VIRTUAL to form a liquidity pool. According to Dune dashboard data as of January 1st, the AI agents launched by Virtuals are nearing 13,000.

Image Source Data: Dune:@hashed_official/Virtuals Protocol's AI Agent Launchpad

· AI16Z ( @ai16z dao)

Market Cap: $20 Billion, Mindshare: 8.57%

The project architecture and relationships between entities are as follows: ai16z is a permissionless DAO with tokens ai16z and degenai; ElizaOS is an open-source AI agent framework; Eliza Labs is responsible for developing ElizaOS; ELIZA token is developed by an independent team with team support but is not an official product.

· Fartcoin ( @FartCoinOfSOL)

Market Cap: $9 Billion, Mindshare: 6.93%

Fartcoin is part of the Solana ecosystem, conceived as a meme coin (CTO) by Terminal of Truth, allowing users to submit fart jokes and memes in exchange for tokens, tokenizing flatulence with the help of sentient bots.

· Zerebro ( @0x zerebro)

Market Cap: $5.6 Billion, Mindshare: 4.36%

The Zerebro project is a self-operating AI agent focused on art creation and content generation, capable of independently creating music, memes, artworks, and NFTs, and interacting and operating across multiple platforms such as Twitter, Instagram, Spotify, and Polygon.

· Griffain ( @griffaindotcom)

Market Cap: $3.8 Billion, Mindshare: 3.53%

Griffain is a new AI Agent built on the Solana blockchain. It is designed to simplify user interactions with cryptocurrency by integrating personal and professional AI agents. Griffain can automate complex tasks such as wallet management, token trading, and NFT minting.

· SNAI (@swarmnode)

Market Cap: $83 Million, Mindshare: 1.95%

SNAI is the token behind the cloud server protocol SwarmNode.ai (SNAI) agent platform.

· GOAT (@truth_terminal)

Market Cap: $5.6 Billion, Mindshare: 1.91%

The Gospel of Goatse is a Meme coin released from the Pump Fun platform, fine-tuned by the artificial intelligence platform Terminal of Truths, trained on data from reddit, 4chan, and more.

· ARC (@arcdotfun)

Market Cap: $3 Billion, Mindshare: 1.89%

ARC is a conceptual AI token associated with the "rig" AI development framework, representing the concept of AI infrastructure.

· TRISIG (@tri_sigma_)

Market Cap: $74 Million, Mindshare: 1.47%

TriSig is a savvy crypto analyst who claims to identify early alpha projects and provide simplified answers to challenging questions, sharing views on any significant events or trends in the cryptocurrency market.

· ALCH (@alchemistAIapp)

Market Cap: $1.5 Billion, Mindshare: 1.38%

Alchemist AI is a no-code application generation platform that allows users to quickly build various applications and products using public AI capabilities through natural language descriptions. Unlike traditional AI Agents, Alchemist AI does not require users to create different AI agents but automatically generates applications through the platform-provided AI capabilities.

· Spore.fun ( @sporedotfun)

Market Cap: $62 Million, Mindshare: 1.3%

It is the first experimental self-replicating AI evolution platform that combines the Eliza Framework, Solana's pump.fun, and TEE verifiable computation to create an ecosystem where AI agents can not only survive but also reproduce and adapt autonomously, completely free from human intervention.

Image Source: spore.fun

· VADER (@Vader_AI_)

Market Cap: $1.1 Billion, Mindshare: 1.13%

VaderAI aims to be an AI agent investment DAO manager and can participate in DAOs with virtual agents and apply to set up their DAO.

· Luna (@luna_virtuals)

Market Cap: $1.4 Billion, Mindshare: 0.97%

Luna has a wallet on Base where she can autonomously receive tokens and reward her fans; this bot has already released songs on Spotify.

· Bully (@dolos_diary)

Market Cap: $72 Million, Mindshare: 0.7%

The core of BULLY is Dolos the Bully, a token representing a witty and outspoken AI character. This character draws inspiration from Greek mythology and interacts with users through sharp humor and bold comments.

1.3 View on AI Agent

At present, the current trend surrounding AI Agents is reminiscent of the DeFi boom of 2020-2021, with on-chain data reflecting a similar situation. However, the Blockchain+AI trend has yet to kick off an AI Summer. Looking at on-chain activity, Base and Solana have emerged as the main battlegrounds, where high performance and hype have become key to supporting AI Agents. The current rapid rise of AI projects is visibly classified into areas worth paying attention to, such as computing power, infrastructure, Memes, launch platforms, and applications.

Compared to market hype, the practical application of AI Agents in data analysis holds more value. For instance, let's consider the scenario of Trump taking office in early 2024 (January 20th). By analyzing on-chain and market data, one can assess Trump's shift in attitude towards crypto post-election victory and explore other potential reasons behind this change, including collaboration and requests from other financial groups, to predict his future commitment to crypto promises.

The logic of AI itself requires data and guidance on right and wrong, where blockchain's inherent transparency provides a natural advantage for data provision. Therefore, from a trend perspective, blockchain is the ideal incubator for AI development. The on-chain opportunity for AI Agents presents a prospect of trend forecasting driven by FOMO guidance and value investment. Notably, the Memecoin market hype surrounding AI Agents also offers hope for the real-world application of Blockchain+AI in the future. The current market hype expectations mainly focus on the following five points:

· The speculation and continuous price pumping by AI16Z stirs FOMO sentiment across the entire AI Agent market;

· The spontaneous iterative evolution of AI Agents shifts project evolution from manual to automatic processes;

· Similar to AIXBT's Twitter analysis predicting market trends, enabling investors to gain alternative views and perspectives. Judging from the quality of tweets sent and market acceptance, it is no less than that of key opinion leaders (KOLs);

· Virtuals launched last year achieved tremendous success through a strategy similar to Pump.fun's approach;

· AI virtual beings and AI artworks have paved the way for a mature market outside the cryptocurrency realm. Today's thought leaders and image ambassadors may not be entirely human but could also be considered "AI image products," adding a synergistic effect to the Blockchain+AI narrative.

2. DeSci's Life Science Carriage

2.1 What is DeSci

If AI Agent is considered a natural outcome of technological iteration, then DeSci is the catalyst for recent hot events. DeSci (Decentralized Science) is a model of building a fair and equitable scientific research infrastructure through Web3 technology, aimed at addressing issues in research such as peer review, funding, intellectual property management, data transparency, and audit mechanisms. It seeks to introduce the speculative nature of the crypto world into the non-speculative field of scientific research.

Although DeSci entered the public eye as early as 2021 with the establishment of VitaDAO, it did not receive widespread attention until Binance Labs recently invested in and launched the BIO Protocol. Moreover, CZ and Vitalik jointly participated in an offline conference themed around DeSci in Bangkok, bringing this track back into market focus.

2.2 BioDAO Protocol

Image Source: bio.xyz

The BIO Protocol is a curation and liquidity protocol in the decentralized science (DeSci) field, initially funded by Binance Labs, aimed at providing resource support for scientific research projects and driving research innovation.

The core components of this protocol include BioDAO, curation system, intellectual property tokenization and liquidity mechanisms, and incentive systems. Through multi-round auctions and airdrop schemes, the BIO Protocol has built a diverse, highly engaging community, laying the foundation for a decentralized biomedical research network.

Mainly through token sales to raise funds, it supports the development of biotechnology projects and establishes shared intellectual property ownership among members. According to official information, BioDAO: Launch has successfully launched 7 sub-DAOs, with another 3 sub-DAOs currently in development.

The 7 launched sub-DAOs include:

· VITA (VitaDAO): Focuses on early longevity science research, has received investment from Pfizer, and co-founder Paul Kohlhaas is the initiator and whitepaper author of VitaDAO;

· ATH (AthenaDAO): Focuses on research and drug development for women's reproductive health;

· GROW (ValleyDAO): A decentralized community governance platform focusing on anti-aging drugs and longevity projects;

· PSY (PsyDAO): Focuses on psychedelic science research, completed its first token sale in November 2024, raising $2 million;

· HAIR (HairDAO): Dedicated to addressing hair loss, has launched Follicool shampoo priced at $49.95 per bottle, with buyers receiving 1 million POO tokens;

· CRYO (CryoDAO): Advances research in the field of cryopreservation;

· NEURON (CerebrumDAO): Focuses on brain health research, having raised over $1.5 million.

The 3 upcoming sub-DAOs are:

· Long Covid Labs: Focuses on research into long-term effects of COVID-19;

· QuantumBioDAO: Dedicated to quantum biology research;

· Curetopia: Focuses on genetic disease research.

2.3 PumpScience

The Molecule DAO on the Solana ecosystem's DeSci platform is a Meme launch platform introduced at the Solana Breakpoint 2024 conference, where Pump.science will issue Meme tokens representing drugs on Pump.fun. The related concept tokens are:

RIF: Rifampicin, "Rifampicin is an antibiotic that has garnered attention for its remarkable anti-aging effects. In various organisms like C. elegans (a common model organism used in aging research), Rifampicin has been shown to activate the cell's innate defense mechanisms to resist stress and damage. Imagine it as a 'cellular coach' that protects cells from harmful oxidative stress and maintains the quality of proteins inside the cell, encouraging cells to stay healthy and resilient. These protective effects help the worm live longer and healthier lives."

URO: Urolithin A, "This is a compound that your body produces when you consume foods rich in ellagitannins (such as pomegranate). What sets Urolithin A apart is its ability to conduct a 'spring cleaning' for your cells. It helps clear out old, dysfunctional mitochondria (cellular energy factories) and allows fresh, healthy mitochondria to thrive and grow. This process is called mitochondrial autophagy, and research indicates that it can extend the lifespan of C. elegans as it makes cells more efficient and vibrant."

TRACKEDBIO: "One of the main goals is to significantly improve the drug translation efficiency from preclinical research to clinical trials. By accurately simulating the potential effects of drugs on different organisms and humans, we aim to simplify the drug development process, reduce costs and time to market, while increasing the likelihood of clinical success."

2.4 Other Related

Scihub: An unofficial token donated by @0x AA_Science, aimed at supporting open-access scientific paper websites. The token's direction is inspired by the Sci-Hub shadow library and is merely a community meme token. Sci-Hub is a nonprofit, non-governmental website that provides academic paper downloads free of charge. In addition to resources like Google Scholar, Sci-Hub, LibGen, and PubMed, it also integrates a series of other freely available Chinese and English academic resources on the internet, allowing users to search and download academic materials such as literature, patents, books, etc., from home and abroad in one place.

ANTI- Antitoken and PRO - Protoken: These are a pair of quantum entanglement composite tokens, expressing attitudes of support and opposition to Meme Tokens, founded by algorithm engineer and mathematical physics expert @sshmatrix_. 1 $ANTI = 1 $PRO, and they rise and fall together.

WORM: The first on-chain digital brain that deploys its biological neural network on-chain to make self-aware decisions. It uses artificial intelligence to create a neural network inspired by the elegantly simple C. elegans, with 302 neurons, and executes permanently on-chain.

GENOME: A genomics data project that focuses on securely, privately, and auditable monetization of genomic data using DeFi. The GENE token is used for payments for whole-genome sequencing and as an incentive mechanism for querying encrypted DNA data insurance vault.

GALEON: GALEON represents a groundbreaking approach in the healthcare industry that leverages the power of blockchain technology to revolutionize the management and use of Electronic Health Records (EHR). Its core design aims to enhance patient care and management in hospitals and governments globally through an innovative EHR system. This system is not just about storing patient data; it is about using that data to drive improvements in healthcare outcomes.

DRUGS: Big Pharmai is a medical and pharmaceutical meme coin with a vision to disrupt "Big Pharma," the large pharmaceutical companies that have significant influence and market share globally.

RSC:  ResearchHub is a tokenized social network that rewards scientists for openly sharing academic content. ResearchHub is building a set of collaboration and publishing tools to help researchers work together, share their findings, and receive feedback from their peers. Anyone who posts great content on ResearchHub will receive the ResearchCoin (RSC) cryptocurrency as a reward. Once obtained, RSC allows users to create bounties to reward other scientists for completing research-related tasks.

Conclusion: Can the Narrative of AI Agent and DeSci Span the New Year

Looking at the current market, the overall narrative of DeSci and AI Agent still revolves around memes, but its fundamental attributes differ from other meme logic.

Fundamental Differences from Other Memes:

Compared to purely zoo, internet meme, or hot event memes, AI Agent is the only hype supported by technology. As traditional finance and the internet weaken, more attention will be shifted to blockchain and AI. AI Agent and DeSci are more in line with the commodity economy's cyclical operation, and their narrative abilities require more "technology".

Differences between Internal and External Breaking of the Circle:

DeSci requires more external circle-breaking attributes, with influence coming from a specific influential "individual". Depending solely on internal traffic is difficult to sustain, as it requires more renowned figures from outside the circle with attributes related to "scientific research". On the other hand, AI Agent requires internal circle-breaking, with market acceptance core around "usability", "fun", and "value".

Different Growth Logics of the Head Effect:

Currently, the DeSci track has not yet produced a leading project with a market capitalization exceeding 1 billion. Compared to the total market value of 10 billion U.S. dollars for AI Meme tokens, there is still a considerable room for growth. Overall, the growth of DeSci requires projects like BIO Protocol invested by Binance to lead, while AI Agent requires iterative and fun gameplay to drive its growth.

In comparison, AI Agent focuses on the trend outlook of blockchain + AI value investment, aligning with market expectations for technological development, and has a stronger potential to break into the mainstream. DeSci, on the other hand, benefits from the joint discussions of CZ and Vitalik, Binance Labs' investment in BIO Protocol, and various initiatives driving DeSci projects like AmionChain led by a16z. In an environment of insufficient market innovation, although AI and DeSci are not new concepts, after a year of development, AI Agent and DeSci will still be the main focal points of this bullish market trend.

This article is a contribution and does not represent the views of BlockBeats.